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Analysis: Research into treating long COVID is stuck

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It’s not yet clear what causes long COVID. Hypotheses include persistent SARS-CoV-2 infection, reactivation of existing latent viruses (such as Epstein-Barr virus), immune responses that never reset after acute infection, a leaky gut, and autoimmunity, according to Michael Peluso, an assistant professor at UCSF who runs one of the country’s largest long COVID observational studies. These are not mutually exclusive, and each suggests a different line of attack.

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